Published: Fri, March 02, 2018
Medical | By Garry George

Varicose veins; sign of deadly clots - study finds

Varicose veins; sign of deadly clots - study finds

Study authors noted that because of the observational study design, "further research is needed to understand whether the association with DVT is causal" or if it reflects a common set of risk factors.

As of now, it is unclear whether common varicose vein treatments like sclerotherapy, elastic stockings, leg elevation and exercise could mitigate the risk of DVT, PE and PAD. Elucidating potential associations between varicose veins and health-threatening diseases is important. They are generally caused by pregnancy or blood vessels weakening with age.

In the United States, almost a quarter (23 per cent) of adults suffer from the condition, which doctors rarely associate with serious health risks.

In any case, they trust irritation in the veins are presumably included, whichever the reason. Chang hypothesized that since patients with varicose veins have increased inflammation, the inflammatory processes may cause abnormal blood clotting.

The study led by researchers including Pei-Chun Chen, adoctoral student from China Medical University in Taiwan, examined 212,984 patients aged 20 years and older with varicose veins, and a control group of equal patients without varicose veins. Both groups contained similar proportions of women - almost 70% - and were the same average age - about 55 years old.

Those with varicose veins had slightly higher incidence rates of and risk for PE (0.48 per 1,000 person-years vs. 0.28 per 1,000 person-years; absolute risk difference, 0.2; 95% CI, 0.16-0.24; HR = 1.73; 95% CI, 1.54-1.94) and PAD (10.73 per 1,000 person-years vs. 6.22 per 1,000 person-years; absolute risk difference, 4.51; 95% CI, 4.31-4.71; HR = 1.72; 95% CI, 1.68-1.77) compared with controls, Chang and colleagues wrote. One person-year is a year lived by each participant for the duration of the study.

Writing in the JAMA medicinal diary, they stated: 'Patients with varicose veins have expanded levels of provocative and ace thrombotic markers'. The team did not analyze ethnic differences since Taiwan's population is nearly entirely Asian, he said.

Varicose veins are not merely a cosmetic or symptomatic concern, because they may be associated with increasing risk of more serious disease.

Dr. Gregory Piazza, cardiovascular medicine specialist at Brigham and Women's Hospital, said the study has a "number of strengths", including the large number of people studied. A new study suggests that the unsightly condition is also linked to potentially deadly blood clots. Moreover, patients with chronic venous diseases have increased leukocyte adhesion and more activated leukocytes.

Whether varicose veins cause these other conditions or share the same cause "remains the focus of ongoing research studies", he said.

In any case, the new examination, by researchers in Taiwan, proposes it ought to be viewed as a notice sign that somebody is in danger of more significant issues. Have you ever experienced a blood clot or deep-vein thrombosis?

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